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Gut-brain communication is modulated by microorganisms including bacteria, archaea, viruses, and unicellular eukaryotes, which together constitute the microbiota

a double glycine-rich domain comprising six Kelch repeat motifs (amino acids 315-359, 361-410, 412-457, 459-504, 506-551, and 553-598)

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In medicine, GA is considered a promising drug due to its powerful anti-inflammatory and anti-oxidant properties, as evidenced by its use in various medical applications ( Until now, GA research has mainly been focused on inflammation (Verma et al., 2013), diabetes (Xu et al., 2021c), intestinal disease research (Yang et al., 2020)